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Pancreatic Pathological Changes in Murine Toxoplasmosis and Possible Association with Diabetes Mellitus.

Asmaa M El-Kady,Amal M Alzahrani,Hayam Elshazly,Eman Abdullah Alshehri,Majed H Wakid,Hattan S Gattan,Wafa Abdullah I Al-Megrin,Mashael S Alfaifi,Khalil Mohamed, Waheeb Alharbi,Hatem A Elshabrawy,Salwa S Younis

Biomedicines（2023）

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Abstract
Acute and chronic toxoplasmosis mice displayed marked pancreatic pathological changes with reduced numbers of islets of Langerhans and insulin-producing-β cells. Since damage of β cells of islets of Langerhans is associated with the development of T1DM, our findings may support a link between infections and the development of T1DM.
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Key words
CD8,T1DM,Toxoplasma gondii,apoptosis,caspase-3,diabetes,insulin,islets of Langerhans
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