The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2 -Negative Women.

Alexey Larionov,Eleanor Fewings,James Redman,Mae Goldgraben,Graeme Clark,John Boice,Patrick Concannon,Jonine Bernstein,David V Conti, The Wecare Study Collaborative Group,Marc Tischkowitz

Cancers（2023）

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摘要

In younger -negative women, the aggregated burden of PGVs in breast cancer risk genes was associated with the increased risk of CBC and was inversely proportional to the age at onset.

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关键词

contralateral breast cancer,exome sequencing,genomics,hereditary breast cancer

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