Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion.

Wenbei Peng,Linlin Ye,Qianqian Xue,Xiaoshan Wei, Zihao Wang,Xuan Xiang,Siyu Zhang,Pei Zhang,Haolei Wang,Qiong Zhou

Cells（2023）

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摘要

This study identifies circCRIM1 as a new tumor suppressor that inhibits tumor immune evasion through a competitive combination with IGF2BP1 to destabilize HLA-F mRNA.

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关键词

NSCLC,circular RNAs,immune evasion

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