Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells.

Paul Bigot, Simon Chesseron,Ahlame Saidi,Damien Sizaret,Christelle Parent,Agnès Petit-Courty,Yves Courty,Fabien Lecaille,Gilles Lalmanach

Antioxidants (Basel, Switzerland)（2022）

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摘要

Alongside its noteworthy resistance to oxidative stress induced by cigarette smoke oxidants and its deleterious elastin-degrading potency, CatS may also have a detrimental effect on the barrier function of epithelial cells through the cleavage of occludin. The obtained data emphasize the emerging role of CatS in smoking-related lung diseases and strengthen the relevance of targeting CatS in the treatment of emphysema and COPD.

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关键词

cathepsin,chronic obstructive pulmonary disease (COPD),cigarette smoke,emphysema,epithelial permeability,lung,occludin,protease

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