SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease.

Carol C L Chen,Augusto Faria Andrade,Nada Jabado

Molecular cell（2023）

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摘要

To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al.1 and Panditharatna et al.2 performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF) chromatin remodeling complex.

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