Hypertrophic genital herpes simplex due to HSV 2 sensitive to maximum dose of oral aciclovir.

In patients who are HIV-positive, genital herpes simplex virus (HSV) infections can present with atypical clinical presentations, representing a diagnostic challenge. Hypertrophic herpes simplex has been classified as a clinical presentation that generally tends to be resistant to treatment with aciclovir. We present a case of hypertrophic HSV due to HSV Type 2, which was sensitive to maximum doses of oral aciclovir.