An “Ideal” Bioisoster of the para-substituted Phenyl Ring

The phenyl ring is a basic structural element in chemistry, and we learn about it already in school. We have developed an “ideal” saturated bioisoster of the para-substituted phenyl ring, - 2 oxabicyclo[2.2.2]octane. Its incorporation into Imatinib drug led to dramatic improvement of all physicochemical properties. This study opens new horizons in science, given the commonplace of the phenyl ring everywhere.