Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes

Xu Hong,Yi Zhou,Zhiyuan Zhu,Yuting Li,Zuo Li,Yuheng Zhang,Xinxin Hu,Fuhai Zhu,Yong Wang,Mingliang Fang,Yichao Huang,Tong Shen

Environment International（2023）

引用 8|浏览28

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摘要

•Case-control study confirms positive link between BPA & obesity with elevated IL-17A.•BPA aggravates adipose tissue inflammation and insulin resistance in obese human and mice.•High-fat-fed IL-17A-/- mice reversed adipose tissue inflammation and insulin resistance even with BPA exposure.•IL-17A mediates the association between BPA exposure and obesity risk.

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关键词

Obesity,Bisphenol A,Inflammation,Insulin resistance,IL-17A

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