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m7G-related gene NUDT4 as a novel biomarker promoting cancer cell proliferation in lung adenocarcinoma.

Yafei Liu,Bin Jiang, Chunjie Lin, Wanyinhui Zhu, Dingrui Chen, Yinuo Sheng,Zhiling Lou,Zhiheng Ji,Chuanqiang Wu,Ming Wu

Frontiers in oncology（2022）

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Abstract
Our study revealed that m7G modification-related proteins are closely related to the tumor microenvironment, immune cell infiltration, responses to immunotherapy, and patients' prognosis in lung adenocarcinoma and could be useful biomarkers for the identification of patients who could benefit from immunotherapy. The m7G modification protein NUDT4 may be a novel biomarker in promoting the progression of lung cancer.
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Key words
N7-methylguanosine modification,NUDT4,immune infiltration,immunotherapy,lung adenocarcinoma,prognosis
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