Characterization of the external exposome and its contribution to the clinical respiratory and early biological effects in children: The PROMESA cohort study protocol.

Diana Marín,Luz Yaneth Orozco,Diana María Narváez,Isabel Cristina Ortiz-Trujillo,Francisco José Molina,Carlos Daniel Ramos,Laura Rodriguez-Villamizar,Shrikant I Bangdiwala,Olga Morales,Martha Cuellar,Luis Jorge Hernández, Enrique Antonio Henao, Verónica Lopera,Andrea Corredor, María Victoria Toro,Helena Groot,Milena Villamil-Osorio, Diego Alejandro Muñoz,Roberto Carlos Hincapié, Ferney Amaya, Ana Isabel Oviedo,Lucelly López,Ricardo Morales-Betancourt,Beatriz Elena Marín-Ochoa,Oscar Eduardo Sánchez-García, Juan Sebastián Marín, José Miguel Abad, Julio Cesar Toro, Eliana Pinzón,Juan José Builes,Zulma Vanessa Rueda

PloS one（2023）

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摘要

To estimate i) The toxic effect of particulate matter transcending the approach based on pollutant concentration levels; ii) The risk of developing an upper and lower ARI, based on different exposure windows; iii) A baseline of early biological damage in children under five, and describe its progression after a one-year follow-up; and iv) How physical and chemical PM2.5 characteristics influence toxicity and children's health.

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关键词

external exposome,clinical respiratory,early biological effects

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