Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.

Romain Ferru-Clément,Gabrielle Boucher,Anik Forest,Bertrand Bouchard,Alain Bitton,Sylvie Lesage,Phil Schumm,Mark Lazarev,Steve Brant,Richard H Duerr,Dermot P B McGovern,Mark Silverberg,Judy H Cho,Ashwin Ananthakrishnan,Ramnik J Xavier,John D Rioux,Christine Des Rosiers

Inflammatory bowel diseases（2023）

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摘要

Untargeted lipidomic analyses uncovered perturbations in the circulating human CD lipidome, likely resulting from multiple pathogenic mechanisms. Models using as few as 5 biomarkers had strong disease classifier characteristics, supporting their potential use in diagnosis or prognosis.

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关键词

Crohn’s disease,comprehensive untargeted lipidomics,lipid biomarkers,subtype stratification

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