Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury.

Benjamin E Zusman,Yijen Wu,Patrick M Kochanek,Vincent E Vagni,Keri Janesko-Feldman,Volodymyr Gerzanich,J Marc Simard,Katherine Karahalios,Sandra Mihaljevic,Sudhanshu Raikwar,Anupama Rani,Jarrod Rulney,Shashvat M Desai,Joshua Catapano,Ruchira M Jha

Critical care medicine（2023）

Cited 3|Views22

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Abstract

High-dose glibenclamide benefitted hematoma volume, vasogenic edema, cytotoxic edema, and BBB integrity after isolated brain contusion. Hematoma and cytotoxic edema effects were acute; longer treatment windows may be possible for vasogenic edema. Our findings provide new insights to inform interpretation of ongoing trials as well as precision design (dose, sample size estimation, patient selection, outcome selection, and Bayesian analysis) of future TBI trials of glibenclamide.

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Key words

cerebral edema,cytotoxic edema,glibenclamide/glyburide,hemorrhage progression,magnetic resonance imaging edema endophenotypes,traumatic brain injury,vasogenic edema

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