Multiple predictive biomarker testing in melanoma: Another challenge in identifying the optimal approach on cytological samples.

Antonino Iaccarino,Mariantonia Nacchio,Gennaro Acanfora,Pasquale Pisapia,Umberto Malapelle,Claudio Bellevicine,Giancarlo Troncone,Elena Vigliar

Cytopathology : official journal of the British Society for Clinical Cytology（2023）

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摘要

We highlighted the feasibility of assessing PD-L1 expression levels in residual CB material from metastatic melanomas previously tested for BRAF and NRAS mutations. Moreover, we pointed out that FNC needle rinses may be an alternative source of nucleic acids for molecular testing, preserving CB material for immunocytochemistry evaluation.

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PD-L1,fine needle cytology,immunotherapy,melanoma,molecular biology

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