MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma.

Lu Bai,Ran Huo,Guotao Fang,Tiantian Ma,Yanhong Shang

Frontiers in oncology（2023）

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摘要

High expression of MMP11 was associated with EGFR mutations. Patients with EGFR-mutant LUAD with high expression of MMP11 responded poorly to immunotherapy, and the percentage of T cell CD8+ and NK cells in immune cell infiltration was lower in MMP11. Consequently, MMP11 is related to the immunological microenvironment of EGFR-mutant lung adenocarcinoma, which may be a predictor of possible immunotherapeutic response.

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关键词

epidermal growth factor receptor (EGFR),immune microenvironment,immunotherapy,lung adenocarcinoma,matrix metalloproteinase 11 (MMP11)

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