Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

Maria Buur Nordskov Gabe,Liv von Voss Christensen,Jenna Elizabeth Hunt,Sarina Gadgaard,Lærke Smidt Gasbjerg,Jens Juul Holst,Hannelouise Kissow,Bolette Hartmann,Mette Marie Rosenkilde

British Journal of Pharmacology（2023）

引用 4|浏览10

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摘要

G protein-biased GLP-2R agonists with diminished receptor desensitization have superior intestinotrophic effects and may represent improved treatment of intestinal insufficiency including SBS.

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关键词

GLP-2 receptor (GLP-2R),bias,glucagon-like peptide-2 (GLP-2),internalization,intestinal growth

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