Non-transferrin-bound iron takes the driver's seat.

Blood（2023）

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摘要

In this issue of Blood, Charlebois et al(1) report that non-transferrin-bound iron (NTBI) is the primary driver of bone morphogenetic protein 6 (BMP6) expression in liver sinusoidal endothelial cells (LSECs) during iron overload. This finding is important because LSEC-derived BMP6 prompts the liver to produce hepcidin, the chief iron-regulatory hormone that regulates body iron balance.

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iron,seat,drivers,transferrin-bound

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