Myeloid Maturity: ATRA to Enhance Anti-PD-1?
Clinical cancer research : an official journal of the American Association for Cancer Research（2023）
摘要
Myeloid-derived suppressor cells (MDSC) are associated with resistance to anti-PD-1 therapies. All-trans retinoic acid (ATRA) may induce maturation of MDSCs and alter their immunosuppressive effects. Adding ATRA to pembrolizumab may target this resistance mechanism to enhance the overall impact of anti-PD-1-based immunotherapy. See related article by Tobin et al., p. 1209.
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关键词
enhance anti–pd-1,atra
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