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Study on the hepatotoxicity and potential mechanism of gefitinib based on CYP450 in mice and AML12 cells.

Xiaoting Yin, Suzhen Ma,Mengyuan Li,Shuaifei Lu,Changjing Zhang,Hui Liu,Caiyin Li,Pan Su,Ming Bai,Yucheng Li

The Journal of pharmacy and pharmacology（2023）

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Abstract
Our results suggested that the hepatotoxicity gefitinib may be associated with CYP1A1, CYP2D9 and CYP2D10. These findings will contribute to a better understanding of the mechanism of gefitinib hepatotoxicity.
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Key words
CYP450,gefitinib,hepatotoxicity
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