Nasal epithelial cell culture fluorescence recovery after photobleaching predicts cystic fibrosis therapeutic response.

Timothy E Corcoran,Carol A Bertrand,Michael M Myerburg,Daniel J Weiner,Sheila A Frizzell,Anna Li, Brittani Agostini,Robert S Parker,Monica E Shapiro,Ashok Muthukrishnan,Nicholas D Hages, Brian P Mulhern,Joseph M Pilewski

ERJ open research（2022）

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摘要

Our results demonstrate the utility of HNE cultures for assessing therapeutic response for hydrating therapies. measurements of FRAP were particularly useful for predicting response and for characterising important properties of ASL mucus that were ultimately reflected in lung physiology.

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关键词

cystic fibrosis,fluorescence,nasal

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