Inhibition of PI3K/Akt/mTOR signaling by NDRG2 contributes to neuronal apoptosis and autophagy in ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association（2023）
Abstract
The present study has shown that NDRG2 impairs the PI3K/Akt/mTOR pathway via dephosphorylation to promote neuronal apoptosis and autophagy in IS. These findings provide potential targets for future clinical therapies for IS.
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Key words
Apoptosis,Autophagy,Ischemic stroke,NDRG2,The PI3K/Akt/mTOR pathway
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