Antagonizing EZH2 combined with vitamin D3 exerts a synergistic role in anti-fibrosis through bidirectional effects on hepatocytes and hepatic stellate cells.

Qinghui Zhang,Rongrong Jia,Minjie Chen,Jianjun Wang, Feng Huang,Min Shi,Huiming Sheng,Ling Xu

Journal of gastroenterology and hepatology（2023）

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摘要

VD3 bioactive form 1,25-OH Vitamin D3 is responsible for the anti-fibrosis, which might have bidirectional effects on HSCs by regulating histone modification. The inhibitor of Ezh2 plays a synergistic role in this process.

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关键词

hepatic stellate cell,hepatocyte,liver fibrosis,vitamin D

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