Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes ( UCP1 , UCP2 , and UCP3 ) in epicardial and mediastinal adipose tissue and associations with coronary artery disease.
Archives of endocrinology and metabolism（2023）
Abstract
Our study supports the hypothesis that higher mRNA expression by genes in the epicardial adipose tissue could be a protective mechanism against the production of reactive oxygen species and may guard the myocardium against damage. Thus, UCP levels are essential to maintain the adaptive phase of cardiac injury in the presence of metabolic disorders.
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Key words
Mitochondrial uncoupling proteins,cardiovascular disease,epicardial adipose tissue,mediastinal adipose tissue
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