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Hypermethylation of HIC2 is a potential prognostic biomarker and tumor suppressor of glioma based on bioinformatics analysis and experiments.

Feifei Luo,Yifu Liao, Endong Cao,Yong Yang,Kai Tang,Dexiang Zhou,Dong Zhou,Haiping Cai

CNS neuroscience & therapeutics（2023）

Cited 4|Views15
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Abstract
Our findings suggest that HIC2 represents a tumor suppressor gene and prognostic biomarker for glioma progression and that overexpression of HIC2 inhibits the proliferation of glioma in vitro and in vivo by interacting with RNF44 and PTPRN2.
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Key words
DNA methylation,HIC2,glioma,prognostic biomarkers,tumor suppressor gene
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