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The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice

Barbara Yang,Hazel Wilkie,Mrinmoy Das,Maheshwor Timilshina,Wayne Bainter,Brian Woods,Michelle Daya,Meher P. Boorgula,Rasika A. Mathias,Peggy Lai,Carter R. Petty,Edie Weller,Hani Harb,Talal A. Chatila,Donald Y.M. Leung,Lisa A. Beck,Eric L. Simpson,Tissa R. Hata,Kathleen C. Barnes,Wanda Phipatanakul

Journal of Allergy and Clinical Immunology（2023）

Cited 4|Views58
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Abstract
The IL-4Rα R576 polymorphism predisposes to more severe AD and increases allergic skin inflammation in mice.
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Key words
Atopic dermatitis,IL-4Rα R576 polymorphism,allergic skin inflammation
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