Metabolic landscape dysregulation in bronchoalveolar lavage fluid of checkpoint inhibitor pneumonitis
Clinical Immunology(2023)
摘要
•Relative LC and IPF, CIP is associated with an intermediate metabolic profile.•Tumor-associated glycosylation is suppressed in patients with CIP.•Dysregulated polyamines and lipids contribute to inflammatory environment in CIP.•CD8+ T cells in the BALF of CIP patients correlate with enriched metabolites.
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关键词
Lung cancer,Checkpoint inhibitor pneumonitis,Idiopathic pulmonary fibrosis,Bronchoalveolar lavage fluid,Metabolomics analysis,Flow cytometry
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