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Acute and long-term immune responses to SARS-CoV-2 infection in unvaccinated children and young adults with inborn errors of immunity.

Ana García-García,Claudia Fortuny,Victoria Fumadó,Iolanda Jordan, Laura Ruiz-López,Europa Azucena González-Navarro,Natalia Egri,Ana Esteve-Solé,Yiyi Luo,Alexandru Vlagea,Manel Monsonís Cabedo,Cristian Launes, Aleix Soler,Anna Codina,Manel Juan,Mariona Pascal,Angela Deyà-Martínez,Laia Alsina

Frontiers in immunology（2023）

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Abstract
Our IEI pediatric cohort had a higher COVID-19 pneumonia rate than the general age-range population, with lower humoral and cellular responses in the acute phase (even lower compared to the reported IEI serological response after SARS-CoV-2 vaccination), and weaker humoral responses at 6 months after infection compared with HC.
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Key words
COVID-19,SARS-CoV-2,cellular immunity,children,humoral immunity,primary immunodeficiency diseases
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