Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury.

Qing Zhang,Beibei Yu,Yongfeng Zhang,Yunze Tian,Shijie Yang,Yongfeng Chen,Haining Wu

Frontiers in immunology（2023）

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摘要

In the subacute phase of SCI, in macrophages/microglia may be key therapeutic targets to promote nerve regeneration. In addition, low-dose decitabine may promote spinal cord regeneration by regulating the polarization state of macrophages/microglia.

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关键词

ScRNA-seq,decitabine,immune infiltration,macrophages/microglia,spinal cord injury

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