Negative correlation between serum pyruvate kinase M2 and cognitive function in patients with cerebral small vessel disease.

Laifang Bian,Yong Zhou,Dongmei Zhang,Tiantian Jiang,Can Xing, Xingyao Wu,Tianle Wang,Xiangyang Zhu

Clinical neurology and neurosurgery（2023）

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摘要

The present findings indicated that the serum PKM2 level was positively correlated with HOMA-IR, WMH, and enlarged perivascular spaces and negatively correlated with cognitive function in CSVD patients.

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关键词

CSVD—Insulin resistance—Vascular cognitive impairment,PKM2—White matter hyperintensities,Pyruvate kinase muscle isozyme 2,VCI,WMH—Cerebral small-vessel disease

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