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Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis

Lingwen Gu,Jing Lin,Qian Wang,Lina Zhang,Min Yin, Hao Lin,Hengrui Zheng,Guiqiu Zhao,Cui Li

International Immunopharmacology（2023）

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Abstract
•DMF exerts prominent antifungal effects.•DMF ameliorates corneal inflammation in fungal keratitis by inhibiting pyroptosis.•Nrf2 participates in the downregulation of pyroptosis caused by DMF.•DMF notably alleviates corneal disease caused by fungal infection.
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Key words
Fungal keratitis,Dimethyl fumarate,Aspergillus fumigatus,Pyroptosis,Nrf2
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