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Assessment of the soluble proteins HMGB1, CD40L and CD62P during various platelet preparation processes and the storage of platelet concentrates: The BEST collaborative study.

Fabrice Cognasse,Hind Hamzeh Cognasse,Marie Ange Eyraud,Amélie Prier,Charles Antoine Arthaud,Pierre Tiberghien,Stephane Begue,Dirk de Korte,Eric Gouwerok,Andreas Greinacher,Konstanze Aurich,Femke Noorman,Larry Dumont,Kathleen Kelly,Marc Cloutier,Renée Bazin,Rebecca Cardigan,Sian Huish,Peter Smethurst,Dana Devine,Peter Schubert,Lacey Johnson,Denese C Marks

Transfusion（2023）

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Abstract
The HMGB1 release mechanism/intracellular pathways appear to differ from sCD62P and sCD40L. The extent to which these differences affect patient outcomes, particularly post-transfusion platelet increment and adverse events, warrants further investigation in clinical trials with various therapeutic indications.
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Key words
inflammation,platelets,storage lesion,transfusion
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