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2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide analogs as potential antagonists of Urotensin II receptor

Ajay Soni,Subham Saha,Aditi Agarwal, Abdul Rehman Abdul Rauf,Rakesh Kumar Singh,Mahesh Seth,Shashi Kant Singh,Sandeep Sinha,Raj Kumar Shirumalla,Shinji Marumoto,Ruchi Tandon

Journal of Receptors and Signal Transduction（2023）

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Abstract
We report herewith identification of 2-{-[(2,4,5-trichlorophenoxy)acetyl]--methylamino}-3-pyrrolidinepropanamides series to obtain novel small molecule antagonists of Urotensin II receptor with acceptable pharmacological profile.
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GPCRs,Receptors,calcium release,cardiovascular,radio-ligand binding,small molecule antagonists
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