A polymerase mechanism-based strategy constructing attenuated clones of enterovirus for vaccine vector development

Chengyuan Ji,Yao Zhang,Yiqiu Feng,Xinqin Zhang, Kaicheng Wang,Jiale Ma,Zihao Pan,Huochun Yao

Virology（2023）

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摘要

•Selection of strains with host tropism as a vaccine candidate.•Identify conserved lysine residues in the RDRP of most RNA viruses.•Mutate a conserved lysine residue in the RDRP of enterovirus to develop a live attenuated vaccine vector.

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关键词

enterovirus,vaccine,mechanism-based

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