Modeling C3 glomerulopathies: C3 convertase regulation on an extracellular matrix surface.

Sofiya Pisarenka,Nicole C. Meyer,Xue Xiao,Renee Goodfellow,Carla M. Nester,Yuzhou Zhang,Richard J. H. Smith

Frontiers in immunology（2022）

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摘要

We conclude that this ECM-based model of C3G offers a replicable method by which to evaluate the variable activity of the complement system in C3G, thereby offering an improved understanding of the different factors driving this disease process.

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关键词

C3 convertase,C3 glomerulopathies,C3 nephritic factor (C3Nef),complement regulation,extracellar matrix,factor B (FB),factor H (FH)

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