Promoters vs. telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology

Shereen A. Howpay Manage,Judy Zhu,Aaron M. Fleming,Cynthia J. Burrows

RSC Chemical Biology（2023）

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摘要

The DNA repair endonuclease APE1 is responsible for the cleavage of abasic sites (AP) in DNA as well as binding AP in promoter G-quadruplex (G4) folds in some genes to...

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关键词

telomeres,folds,abasic sites,ap-endonuclease,g-quadruplex

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