VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion.

Ruihua Sun,Junkui Shang,Xi Yan,Jingran Zhao,Wan Wang,Wenjing Wang,Wei Li,Chenhao Gao,Fengyu Wang,Haohan Zhang,Yanliang Wang,Huixia Cao,Jiewen Zhang

Journal of Alzheimer's disease : JAD（2023）

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摘要

Injury of the BBB may not be the main reason for persistent loss of cortical neurons following CCH. The continuous inflammatory response within blood vessels maybe an important factor in the continuous loss of cortical neurons following CCH.

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关键词

Blood-brain barrier,VCAM1,chronic cerebral hypoperfusion,inflammation,neuron

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