Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure - a systematic review and meta-analysis.

Based on a systematic review and meta-analysis of articles published in PubMed, Embase, Cochrane, and Web of Science, we identified nine articles that provide evidence of the relationship between persistent organic pollutants and hyperuricemia. Our researchers assess the quality of the included studies and their risk of bias using the recommended method and tool. This study uses meta-analyses of the random effects of each exposure and outcome to estimate combined odds ratios (ORs) and 95% confidence intervals (CIs). We found that the risk of hyperuricemia was strongly associated with three perfluorinated compounds, PFNA, PFOA, and PFOS, with the OR(95%CI) of 1.26 (1.07-1.47), 1.44(1.15-1.79), and 1.23(1.01-1.50) respectively. We also found a weak association between two other perfluorinated compounds, PFDA and PFHxS. Other than that, the summary ORs (95% CIs) of incident hyperuricemia were 2.34 (1.79-3.08) for DDT, 3.25(2.40-4.39) for DDE, 2.57 (1.37-4.81) for PCBs and 3.05(2.22-4.19) in trans-nonanchlor. Therefore, DDT and its breakdown product, DDE, PCBs, and trans-nonanchlor have also been linked with an increased risk of hyperuricemia in humans. This study finds that persistent organic pollutant is a critical factor for hyperuricemia, and further studies in specific regions will be considered in the future.