Nature can still be the strongest help against aging and neurodegeneration: the sirtuins way.

Unfortunately,aging is not a reversible phenomenon and the processes of senescence are unavoidable.However,the biological effects of aging may be turned back,and with those,it can be reduced risk of all age-related illnesses,such as cardiovascular diseases,cancer,diabetes,and neurodegenerative diseases,including Alzheimer's disease(AD),and Parkinson's diseases(PD).In the latest decades,scientists worldwide therefore have developed several strategies,either natural or pharmacological,to counteract aging phenomena,with the final goal to improve human life expectancy.The main scientific rationale beyond these strategies focuses on the opportunity to reduce chronic low-grade inflammation(inflammaging),the increase in oxidative stress damage,and the impairment in the immune system,all typical mechanisms of senescence(Verdaguer et al.,2012).Then,most innovative anti-aging treatments are mainly based on pharmacological senolytic therapeutics,plasma membrane redox system activators,epigenetic modulators,and stem cell therapies(Verdaguer et al.,2012).More specifically,novel therapies against AD include humanized monoclonal antibodies,such as bapineuzumab and solanezumab,targeting senile plaques(Rygiel,2016);and those against PD include new pharmaceutical compounds,such as Neu 120,and V1512,EPI-589,targeting neurological central motor system(Zhong et al.,2022).