Clinical performance of MRI & biomarkers for prostate cancer diagnosis in men at high genetic risk.

We found that screening men at high genetic risk for PCa must be based on mpMRI without pre-screening based on PSA>3ng/mL, to avoid missing too much ISUP>1 tumours and to significantly reduce the number of unnecessary biopsies. However, urinary markers or PSAD≥0.1ng/mL/cc when mpMRI was negative increased the detection of ISUP>1 cancers. We suggest that a baseline mpMRI be discussed for men at high genetic risk from 40 years-old.