Knee immobilization reproduces key arthrofibrotic phenotypes in mice.

Louis Dagneaux,Afton K Limberg,Aaron R Owen,Jacob W Bettencourt,Amel Dudakovic,Banu Bayram,Naomi M Gades,Joaquin Sanchez-Sotelo,Daniel J Berry,Andre van Wijnen,Mark E Morrey,Matthew P Abdel

Bone & joint research（2023）

Cited 0|Views12

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Abstract

This study established a novel mouse model of robust knee contracture without evidence of OA. This was appreciated consistently after eight weeks of immobilization and was irrespective of length of remobilization. As such, this arthrofibrotic model provides opportunities to investigate molecular pathways and therapeutic strategies.Cite this article: 2023;12(1):58-71.

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Key words

Animal models,Contracture,Fibrosis,Genetic predisposition,Knees,Murine,articular injury,cartilage degeneration,contractures,extension angles,histological analysis,immobilization,mouse models,sutures

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