Knee immobilization reproduces key arthrofibrotic phenotypes in mice.
Bone & joint research(2023)
Abstract
This study established a novel mouse model of robust knee contracture without evidence of OA. This was appreciated consistently after eight weeks of immobilization and was irrespective of length of remobilization. As such, this arthrofibrotic model provides opportunities to investigate molecular pathways and therapeutic strategies.Cite this article: 2023;12(1):58-71.
MoreTranslated text
Key words
Animal models,Contracture,Fibrosis,Genetic predisposition,Knees,Murine,articular injury,cartilage degeneration,contractures,extension angles,histological analysis,immobilization,mouse models,sutures
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined