An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies.

Shervin Tabrizi,Carmen Martin-Alonso,Kan Xiong,Timothy Blewett,Sainetra Sridhar,Zhenyi An,Sahil Patel,Sergio Rodriguez-Aponte,Christopher A Naranjo,Shih-Ting Wang,Douglas Shea,Todd R Golub,Sangeeta N Bhatia,Viktor Adalsteinsson,J Christopher Love

biorxiv（2023）

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摘要

Blood-based, or "liquid," biopsies enable minimally invasive diagnostics but have limits on sensitivity due to scarce cell-free DNA (cfDNA). Improvements to sensitivity have primarily relied on enhancing sequencing technology ex vivoin vivo

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关键词

dna-binding,cell-free

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