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Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity.

Xiaomin Zhang,Limin Cheng,Chengqi Gao,Jing Chen,Shuangye Liao,Yongqiang Zheng,Liping Xu,Jingjing He,Danyang Wang,Ziqian Fang,Jianeng Zhang,Min Yan,Yi Luan,Siyu Chen,Likun Chen,Xiaojun Xia,Chunhao Deng,Guokai Chen,Wende Li,Zexian Liu,Penghui Zhou

Cancer research（2023）

Cited 10|Views57
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Abstract
Androgen signaling induces immunosuppression in cancer by blocking T-cell activity through upregulation of USP18 and subsequent inhibition of NF-κB activity, providing a targetable axis to improve antitumor immunity in males.
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Key words
androgen,sex differences,cancer
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