Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of non-human primates during vision-based behavioral tasks
crossref(2024)
摘要
Non-human primates (NHPs), especially rhesus macaques, have played a
significant role in our current understanding of the neural computations
underlying human vision. Apart from the established homologies in the visual
brain areas between these two species, and our extended abilities to probe
detailed neural mechanisms in monkeys at multiple scales, one major factor that
makes NHPs an extremely appealing animal model of human-vision is their ability
to perform human-like visual behavior. Traditionally, such behavioral studies
have been conducted in controlled laboratory settings. Such in-lab studies
offer the experimenter a tight control over many experimental variables like
overall luminance, eye movements (via eye tracking), auditory interference etc.
However, there are several constraints related to such experiments. These
include, 1) limited total experimental time, 2) requirement of dedicated human
experimenters for the NHPs, 3) requirement of additional lab-space for the
experiments, 4) NHPs often need to undergo invasive surgeries for a head-post
implant, 5) additional time and training required for chairing and head
restraints of monkeys. To overcome these limitations, many laboratories are now
adapting home-cage behavioral training and testing of NHPs. Home-cage
behavioral testing enables the administering of many vision-based behavioral
tasks simultaneously across multiple monkeys with much reduced human personnel
requirements, no NHP head restraint, and provide NHPs access to the experiments
without specific time constraints. To enable more open-source development of
this technology, here we provide the details of operating and building a
portable, easy-to-use kiosk for conducting home-cage vision-based behavioral
tasks in NHPs.
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