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Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques.

Edith M Walker,Kristen M Merino,Nadia Slisarenko,Brooke F Grasperge,Smriti Mehra,Chad J Roy,Deepak Kaushal,Namita Rout

Frontiers in immunology（2023）

Cited 0|Views23
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Abstract
Overall, these data suggest that despite SIV-induced decline in IL-7R expression and IFN-γ production by mycobacterial lipid-reactive T cells, their cytolytic potential is maintained. A deeper understanding of anti-mycobacterial lipid-reactive T cell functions may inform novel approaches to enhance TB control in individuals with or without HIV infection.
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Key words
BCG,SIV,lipid antigen,macaque,tuberculosis,γδT
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