Molecular profile of patients with myelofibrosis: a 10-year experience.

Lara Faria Souza Dias,Carolina Leme de Moura Pereira, Newton de Freitas Centurião,Jade Zezzi Martins do Nascimento,Andreza Alice Feitosa Ribeiro,Nelson Hamerschlak,Carolina Perrone Marques, Ana Carolina Vieira de Lima, Luana Nóbrega da Costa, Anderson Felipe da Silva,Viviane de Jesus Torres Lima,Mariana Nassif Kerbauy,Lucila Nassif Kerbauy,Leonardo Javier Arcuri,Paulo Vidal Campregher, Juliana Dall Agnol da Rocha,Tarcila Santos Datoguia,Fabio Pires de Souza Santos

Einstein (Sao Paulo, Brazil)（2023）

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摘要

The molecular analysis enables estimating the patient's risk and thus instituting more aggressive treatment such as bone marrow transplant for patients at higher risk, being a relevant tool to guide therapy. Given the significance of molecular analysis for therapeutic decision-making in myelofibrosis, collection and disclosure of data on the prevalence of cytogenetic changes and findings of next-generation sequencing in affected patients is important.

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关键词

Primary myelofibrosis,Cytogenetic analysis,Mutation,Prognosis,Bone marrow transplantation

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