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Four-Compartment Diffusion Model of Cortisol Disposition: Comparison With 3 Alternative Models in Current Clinical Use.

Richard I Dorin,Frank K Urban,Ilias Perogamvros,Clifford R Qualls

Journal of the Endocrine Society（2022）

Cited 1|Views11
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Abstract
The proposed 4-compartment diffusion model (Model 4) is consistent with relevant experimental observations and met the greatest number of empiric validation criteria. Cortisol half-life solutions obtained using Model 4 were generalizable between HV and CBG-deficient groups and bolus and continuous modes of hydrocortisone infusion.
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Key words
albumin,compartmental modeling,computer-assisted,corticosteroid binding globulin (CBG),cortisol,hydrocortisone,metabolic clearance rate,numerical analysis,septic shock
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