Synthesis by microwave irradiation, molecular structural analysis and trypanocidal activity of novel pyrazole-tetrahydropyrimidine derivatives.
Current organic synthesis(2023)
Abstract
The attractive features of this synthetic methodology are mild conditions, short reaction time, and low power. All derivatives showed low toxicity in mammalian cells, good oral bioavailability, and did not violate Lipinski´s rule of 5.
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Key words
Heterocycle,Irradiation,Microwave,Pyrazole,Tetrahydropyrimidine,Trypanocidal activity.
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