Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer.

Cellular signalling（2023）

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摘要

This study demonstrates that transcriptional activation of circ_644 upon RUNX3 downregulation drives the malignant development of BCa through the miR-143-3p/MSI2 axis. RUNX3 restoration or specific inhibition of circ_644 or MSI2 may help block BCa progression.

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关键词

Bioinformatics,Bladder cancer,Circ_644,MSI2,RUNX3,microRNA-143-3p

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