The Impact of Poorly Differentiated Histology on Immunotherapy in Advanced Gastrointestinal Cancers.

Amber Draper,Emily H Jung,Yichun Cao, Rami P Atallah,Jeffrey Switchenko,Sujata Kane, Jessica Guadagno,Aaron T Jones,Edith Brutcher,Olatunji B Alese

Oncology（2023）

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摘要

Results from this study demonstrate that poorly differentiated histology was associated with shorter mOS but was not associated with improved PFS in patients treated with CPI. Treatment-naïve patients, moderately differentiated tumors, female gender, ECOG 1, and MSI-High/dMMR were most likely to benefit from CPI.

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关键词

Biomarker,Gastrointestinal cancer,Immunotherapy,Poorly differentiated histology,Survival outcomes

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