Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures.
Metabolism: clinical and experimental(2023)
摘要
Compared to TDF, TAF may alter bioenergetics in immune cells from PWH in vitro and in vivo. The clinical significance in terms of the differential impact caused by TAF versus TDF on mitochondrial function and energy production in immune cells, a regulator of immune function, requires further studied in HIV, preexposure prophylaxis and hepatitis B.
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关键词
Antivirals,HIV,Immune cells,Metabolism,Mitochondria,Tenofovir alafenamide (TAF),Tenofovir disoproxil fumarate (TDF)
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