S1428 Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With History of Alcohol Use Disorder (AUD): Retrospective Study Using NIS (2016 – 2019)

Introduction: Liver is the most common site for intra-abdominal abscess. Pyogenic liver abscess is more common in men compared to women. Risk factors include diabetes mellitus and chronic hepatobiliary disease. Alcohol abuse is known to cause bone marrow suppression and compromised immune system. Limited data are available regarding clinical outcomes in patients with history of alcohol use disorder who are admitted with pyogenic liver abscess. Methods: Using National Inpatient Sample databases from 2016 to 2019. We identified patients presenting with pyogenic liver abscess, the population were then divided based on the presence and absence of alcohol use disorder using appropriate ICD-10-CM/PCS codes. STATA 16.0 software was used for the analysis. Pearson’s Chi-Square test was used to analyze categorical variable, whereas the student t-test was used to analyze continuous variables. Univariate and multivariate logistic regression was used to adjust for potential confounders. Primary outcome was in hospital mortality due to Pyogenic liver abscess in patients with alcohol use disorder. Results: Amongst total of 19,830 patients admitted with pyogenic liver abscess, 1,090 patients had history of alcohol use disorder and 18,740 patients did not. Both groups consisted predominantly of white male patients. Mean LOS was higher in alcohol use disorder group (8±6.08 days) than in non-alcohol use disorder group (7.35±6.34 days ) (P=< 0.001 ). Mean total hospitalization charges were higher in AUD group ($ 20,968) than in the non-AUD group ($ 18,994) (P= < 0.001) Conclusion: Patient with Pyogenic liver abscess with alcohol use disorder history had higher resource utilization, but less odds of mortality. (Table) Table 1. - In-patient outcome comparison of patients with history of alcohol use disorder presenting with pyogenic liver abscess PLA WITH AUD, N(%) PLA WITHOUT AUD, N(%) P value Total 1090(8.92) 18740(91.07) Primary Outcome OR 95 CI P value Mortality 0.511 0.067 - 3.86 < 0.001 Secondary Outcomes Mean Mean P value LOS(days) 8+/-6.08 7.35+/-6.34 < 0.001 Charges(US$) 20968 18994 < 0.001 Demographics Mean Age 57.65+/- 11.45 61.47+/-15.65 Female(%) 205(18.81) 7404(41)